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BCAM / CD239  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: Human Cells  
10238-H08H-200
10238-H08H-100
200 µg 
100 µg 
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発現宿主: Human Cells  
10238-H02H-200
10238-H02H-100
200 µg 
100 µg 
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  • Slide 1
発現宿主: Human Cells  
50960-M02H-50
50960-M02H-20
50 µg 
20 µg 
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  • Slide 1
発現宿主: Human Cells  
50960-M08H-50
50960-M08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: Human Cells  
80222-R08H-50
80222-R08H-100
50 µg 
100 µg 
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  • Slide 1

BCAM / CD239 Related Area

BCAM / CD239 関連経路

    BCAM / CD239 サマリー & タンパク質情報

    BCAM / CD239 背景

    遺伝子の概要: Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. CD239 (BCAM) contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. CD239 may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this BCAM gene.
    General information above from NCBI
    細胞内位置: Membrane; Single-pass type I membrane protein.
    組織特異性: Wide tissue distribution (highest in the pancreas and very low in brain). Closely associated with the basal layer of cells in epithelia and the endothelium of blood vessel walls.
    発生段階: Is under developmental control in liver and may also be regulated during differentiation in other tissues. Up-regulated following malignant transformation in some cell types.
    翻訳後: Epinephrine-stimulated phosphorylation of Ser-621 by PKA enhances adhesion to laminin. {ECO:0000269|PubMed:15975931}.
    シーケンスの類似性: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.; Contains 2 Ig-like V-type (immunoglobulin-like) domains. {ECO:0000305}.
    General information above from UniProt

    The Lutheran (Lu) blood group and basal cell adhesion molecule (BCAM) antigens are both carried by 2 glycoprotein isoforms of the immunoglobulin superfamily representing receptors for the laminin alpha(5) chain. It is a transmembrane receptor with five immunoglobulin-like domains in its extracellular region, and is therefore classified as a member of the immunoglobulin (Ig) gene family. In addition to red blood cells, Lu/BCAM proteins are expressed in endothelial cells of vascular capillaries and in epithelial cells of several tissues. BCAM/LU has a wide tissue distribution with a predominant expression in the basal layer of the epithelium and the endothelium of blood vessel walls. As designated as CD239 recently, BCAM and LU share a significant sequence similarity with the CD146 (MUC18) and CD166, and themselves are adhesion molecules that bind laminin with high affinity. Laminins are found in all basement membranes and are involved in cell differentiation, adhesion, migration, and proliferation. BCAM is upregulated following malignant transformation of some cell types in vivo and in vitro, thus being a candidate molecule involved in tumor progression. In addition, BCAM interacts with integrin in sickle red cells, and thus may potentially play a role in vaso-occlusive episodes.

    BCAM / CD239 代替名

    AU,LU,CD239,MSK19, [homo-sapiens]
    AU,BCAM,CD239,LU,MSK19, [human]
    1200005K12Rik,Bcam,B-CAM,Gplu,Lu, [mouse]
    lu,Gplu,B-CAM,1200005K12Rik, [mus-musculus]

    BCAM / CD239 関連研究

  • Kikkawa Y, et al. (2005) Review: Lutheran/B-CAM: a laminin receptor on red blood cells and in various tissues. Connect Tissue Res. 46 (4-5): 193-9.
  • El Nemer W, et al. (2007) Endothelial Lu/BCAM glycoproteins are novel ligands for red blood cell alpha4beta1 integrin: role in adhesion of sickle red blood cells to endothelial cells. Blood. 109 (8): 3544-51.
  • Colin Y, et al. (2008) Red cell and endothelial Lu/BCAM beyond sickle cell disease. Transfus Clin Biol. 15 (6): 402-5.
  • El Nemer W, et al. (2008) Role of Lu/BCAM in abnormal adhesion of sickle red blood cells to vascular endothelium. Transfus Clin Biol. 15 (1-2): 29-33.
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