クイック注文

CD160/NK1/BY55  Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: Human Cells  
12191-H08H-50
12191-H08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: Human Cells  
50805-M02H-50
50805-M02H-200
50 µg 
200 µg 
Add to Cart
  • Slide 1
発現宿主: Human Cells  
90224-C02H-50
90224-C02H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: Human Cells  
90224-C08H-50
90224-C08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: Human Cells  
90224-CCCH-50
90224-CCCH-100
50 µg 
100 µg 
Add to Cart
  • Slide 1

CD160/NK1/BY55 Related Area

CD160/NK1/BY55 関連経路

    CD160/NK1/BY55 サマリー & タンパク質情報

    CD160/NK1/BY55 背景

    遺伝子の概要: CD160 is an 27 kDa glycoprotein which was initially identified with the monoclonal antibody BY55. Its expression is tightly associated with peripheral blood NK cells and CD8 T lymphocytes with cytolytic effector activity. The cDNA sequence of CD160 predicts a cysteine-rich, glycosylphosphatidylinositol-anchored protein of 181 amino acids with a single Ig-like domain weakly homologous to KIR2DL4 molecule. CD160 is expressed at the cell surface as a tightly disulfide-linked multimer. RNA blot analysis revealed CD160 mRNAs of 1.5 and 1.6 kb whose expression was highly restricted to circulating NK and T cells, spleen and small intestine. Within NK cells CD160 is expressed by CD56dimCD16+ cells whereas among circulating T cells its expression is mainly restricted to TCRgd bearing cells and to TCRab+CD8brightCD95+CD56+CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity for binding to both classical and nonclassical MHC class I molecules.
    General information above from NCBI
    サブユニット構造: Homomultimer; disulfide-linked.
    細胞内位置: Cell membrane; Lipid-anchor, GPI-anchor.
    組織特異性: Expressed in spleen, peripheral blood, and small intestine. Expression is restricted to functional NK and T cytotoxic lymphocytes.
    シーケンスの類似性: Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    CD160 antigen, also known as Natural killer cell receptor BY55 and CD160, is a cell membrane protein which contains one Ig-like V-type (immunoglobulin-like) domain. CD160 is a GPI-anchored lymphocyte surface receptor in which expression is mostly restricted to the highly cytotoxic CD56(dim)CD16(+) peripheral blood NK subset. CD160 is a receptor showing broad specificity for both classical and non-classical MHC class I molecules. CD160 is expressed in spleen, peripheral blood, and small intestine. Expression of CD160 is restricted to functional NK and T cytotoxic lymphocytes. CD160 acts as a co-activator receptor for CD3-induced proliferation of CD4+ CD160+ T cells isolated from inflammatory skin lesions. Unique CD4+ CD160+ lymphocyte subset may play a role in the pathogenesis of skin inflammation. Activated NK lymphocytes release a soluble form of CD160 that functionally impairs the MHC-I-specific cytotoxic CD8(+) T lymphocyte responsiveness.

    Immune Checkpoint
    Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies   Immune Checkpoint Detection: FCM Antibodies
    Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    CD160/NK1/BY55 代替名

    NK1,BY55,NK28, [homo-sapiens]
    BY55,NK1,NK28,RP11-373C9.1,CD160,FLJ46513, [human]
    AU045688,By55,Cd160, [mouse]
    By55,AU045688, [mus-musculus]

    CD160/NK1/BY55 関連研究

  • Barakonyi A. et al., 2004, J Immunol.173 (9): 5349-54.
  • Rabot M. et al., 2006, Transpl Immunol. 17 (1): 36-8.
  • Abecassis S. et al., 2007, J Invest Dermatol. 127?(5): 1161-6.
  • Giustiniani J.?et al., 2007, J Immunol. 178 (3): 1293-300.
  • 注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"