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CD112/Nectin-2/PVRL2  Protein, Antibody, ELISA Kit, cDNA Clone

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10005-H08H-50
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10005-HCCH-50
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10005-H02H-50
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50318-M08H-50
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発現宿主: Human Cells  
80327-R08H-50
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CD112/Nectin-2/PVRL2 Related Area

CD112/Nectin-2/PVRL2 関連経路

    CD112/Nectin-2/PVRL2 サマリー & タンパク質情報

    CD112/Nectin-2/PVRL2 背景

    遺伝子の概要: This PVRL2 gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. Nectin-2 is one of the plasma membrane components of adherens junctions. Nectin-2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
    General information above from NCBI
    サブユニット構造: Can form trans-heterodimers with PVRL3/nectin-3 (By similarity). Interacts with CD226. Binds with low affinity to TIGIT. Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses. {ECO:0000250, ECO:0000269|PubMed:11602758, ECO:0000269|PubMed:15607800, ECO:0000269|PubMed:19011627, ECO:0000269|PubMed:22927415}.
    細胞内位置: Cell membrane; Single-pass type I membrane protein.
    組織特異性: Ubiquitous.
    シーケンスの類似性: Belongs to the nectin family. {ECO:0000305}.; Contains 2 Ig-like C2-type (immunoglobulin-like) domains. {ECO:0000305}.; Contains 1 Ig-like V-type (immunoglobulin-like) domain. {ECO:0000305}.
    General information above from UniProt

    Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

    CD112/Nectin-2/PVRL2 代替名

    CD112/Nectin-2/PVRL2 関連研究

  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.
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