Nectin-2 (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All Nectin-2 reagents are produced in house and quality controlled, including 12 Nectin-2 Antibody, 2 Nectin-2 ELISA, 39 Nectin-2 Gene, 2 Nectin-2 IP Kit, 6 Nectin-2 Lysate, 6 Nectin-2 Protein, 3 Nectin-2 qPCR. All Nectin-2 reagents are ready to use.

Nectin-2 Protein (6)

Nectin-2 Antibody (12)

Nectin-2 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

Nectin-2 cDNA Clone (39)

NM_001042724.1

クローニングベクター cDNA 製品

In lentiviral vector

NM_008990.3

クローニングベクター cDNA 製品

In lentiviral vector

NM_001012064.1

クローニングベクター cDNA 製品

In lentiviral vector

Nectin-2 Lysate (6)

Nectin-2 の背景知識

Cluster of Differentiation 112 (CD112), also known as poliovirus receptor related protein 2 (PVRL2 or PRR2), is a single-pass type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. CD112 protein also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and thus is involved in cell to cell spreading of these viruses. CD112 protein has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 protein can induce NK cell- and CD8+ T cell-mediated cytotoxicity and cytokine secretion. CD112 has been regarded as a critical component in allergic reactions, and accordingly may function as a novel target for anti-allergic therapy.

Nectin-2 の参考文献

  • Bachelet I, et al. (2006) Mast cell costimulation by CD226/CD112 (DNAM-1/Nectin-2): a novel interface in the allergic process. J Biol Chem. 281(37): 27190-6.
  • Wang L, et al. (2009) Molecular cloning, characterization and three-dimensional modeling of porcine nectin-2/CD112. Vet Immunol Immunopathol. 132(2-4): 257-63.