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C8B  Protein, Antibody, ELISA Kit, cDNA Clone

C8B 関連経路

    C8B 関連製品

    C8B 関連製品

    Featured Reagent Products

    C8B サマリー & タンパク質情報

    C8B 背景

    サブユニット構造: Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9.
    細胞内位置: Secreted.
    翻訳後: N-glycosylated; contains one or two bound glycans. Not O- glycosylated.
    疾患関連性: Complement component 8 deficiency, 2 (C8D2) [MIM:613789]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    シーケンスの類似性: Belongs to the complement C6/C7/C8/C9 family.
    Contains 1 EGF-like domain.
    Contains 1 LDL-receptor class A domain.
    Contains 1 MACPF domain.
    Contains 2 TSP type-1 domains.
    General information above from UniProt

    C8B 代替名

    C8B 関連研究