クイック注文

C8A  Protein, Antibody, ELISA Kit, cDNA Clone

C8A Related Area

C8A 関連経路

    C8A サマリー & タンパク質情報

    C8A 背景

    サブユニット構造: Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9. {ECO:0000269|PubMed:17692377, ECO:0000269|PubMed:18440555, ECO:0000269|PubMed:7440581}.
    細胞内位置: Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells.
    疾患関連性: DISEASE: Complement component 8 deficiency, 1 (C8D1) [MIM:613790]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
    シーケンスの類似性: Belongs to the complement C6/C7/C8/C9 family. {ECO:0000305}.; Contains 1 EGF-like domain. {ECO:0000305}.; Contains 1 LDL-receptor class A domain. {ECO:0000255|PROSITE-ProRule:PRU00124}.; Contains 1 MACPF domain. {ECO:0000255|PROSITE-ProRule:PRU00745}.; Contains 2 TSP type-1 domains. {ECO:0000255|PROSITE-ProRule:PRU00210}.
    General information above from UniProt

    C8A 代替名

    C8A 関連研究

    注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"