C1QB (タンパク質 | 抗体 | cDNA クローン | ELISA キット)

All C1QB reagents are produced in house and quality controlled, including 1 C1QB Antibody, 26 C1QB Gene, 1 C1QB Lysate, 1 C1QB Protein, 2 C1QB qPCR. All C1QB reagents are ready to use.

C1QB Protein (1)

C1QB Antibody (1)

C1QB cDNA Clone (26)

NM_000491.3

クローニングベクター cDNA 製品

In lentiviral vector

NM_009777.2

クローニングベクター cDNA 製品

In lentiviral vector

C1QB Lysate (1)

ほかの人気製品

C1QB 関連の研究分野

C1QB の背景知識

Complement Component 1, q subcomponent (C1q) associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Southern blot analysis of chromosomal DNA from vertebrate species demonstrated highest similarity between the C1qB genes, followed by C1qC and finally C1qA. Sequence comparison of C1q from three different species have shown that the B chains have the strongest similarity. C1q was already present at embryonic day 14 (E14) and showed little change in abundance through six weeks postnatal. At E16, C1qB mRNA was present at high abundance in putative microglia/macrophages in cortical marginal and intermediate zones, and hippocampal analge.

C1QB の参考文献

  • Pasinetti GM, et al. (1992) Complement C1qB and C4 mRNAs responses to lesioning in rat brain. Experimental neurology. 118(2): 117-25.
  • Johnson SA, et al. (1994) Expression of complement C1qB and C4 mRNAs during rat brain development. Brain Res Dev Brain Res. 80(1-2): 163-74.
  • Grewal RP,et al. (1999) C1qB and clusterin mRNA increase in association with neurodegeneration in sporadic amyotrophic lateral sclerosis. Neuroscience letters. 271(1): 65-7.
  • Spielman L, et al. (2002) Induction of the complement component C1qB in brain of transgenic mice with neuronal overexpression of human cyclooxygenase-2. Acta neuropathologica. 103(2): 157-62.