クイック注文

B7-H4/Vtcn1/B7S1  タンパク質

All B7-H4 Reagents

発現宿主: Human Cells  
10738-H08H-50
10738-H08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: Human Cells  
10738-H02H-50
10738-H02H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: Human Cells  
50017-MCCH-50
50017-MCCH-100
50 µg 
100 µg 
Add to Cart
  • Slide 1
発現宿主: Human Cells  
50017-M02H-50
50017-M02H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1

Browse B7-H4/Vtcn1/B7S1 Products by

B7-H4/Vtcn1/B7S1 Related Area

B7-H4/Vtcn1/B7S1 関連経路

    B7-H4/Vtcn1/B7S1 サマリー & タンパク質情報

    B7-H4/Vtcn1/B7S1 背景

    遺伝子の概要: This gene encodes a protein belonging to the B7 costimulatory protein family. Proteins in this family are present on the surface of antigen-presenting cells and interact with ligand bound to receptors on the surface of T cells. Studies have shown that high levels of the encoded protein has been correlated with tumor progression. A pseudogene of this gene is located on chromosome 20. Multiple transcript variants encoding different isoforms have been found for this gene
    General information above from NCBI
    細胞内位置: Cell membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000305}. Note=Expressed at the cell surface. A soluble form has also been detected. {ECO:0000255, ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16782226}.
    組織特異性: Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis. {ECO:0000269|PubMed:12818165, ECO:0000269|PubMed:14568939, ECO:0000269|PubMed:15878339, ECO:0000269|PubMed:16606666, ECO:0000269|PubMed:16782226, ECO:0000269|PubMed:16798883, ECO:0000269|PubMed:17509674}.
    誘導: Up-regulated by IL6/interleukin-6 and IL10/interleukin-10 and inhibited by CSF2/GM-CSF and IL4/interleukin-4 on antigen-presenting cells (APCs). {ECO:0000269|PubMed:16606666, ECO:0000269|PubMed:16785496, ECO:0000269|PubMed:17875732}.
    翻訳後: N-glycosylated. {ECO:0000269|PubMed:15878339}.
    シーケンスの類似性: Belongs to the immunoglobulin superfamily. BTN/MOG family. {ECO:0000250|UniProtKB:Q5ZPR3}.; Contains 2 Ig-like V-type (immunoglobulin-like) domains. {ECO:0000255}.
    General information above from UniProt

    V-set domain-containing T-cell activation inhibitor 1, also known as B7X, B7H4, B7S1, and VTCN1, is a single-pass type? membrane protein belonging to the B7 family of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands on T lymphocytes. They provide costimulatory signals that regulate T cell responses. A soluble form of B7H4 has also been detected. B7X / VTCN1 / B7H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, B7X / VTCN1 / B7H4 plays an important role, together with regulatory T-cells(Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. B7X / VTCN1 / B7H4 is also involved in promoting epithelial cell transformation. This membrane protein can be up-regulated by IL6 / interleukin-6 and IL10 / interleukin-10 and inhibited by CSF2 / GM-CSF and IL4 / interleukin-4 on antigen-presenting cells.

    Immune Checkpoint
    Immune Checkpoint Detection: Antibodies   Immune Checkpoint Detection: ELISA Antibodies   Immune Checkpoint Detection: IHC Antibodies
    Immune Checkpoint Proteins
    Immune Checkpoint Targets   Co-inhibitory Immune Checkpoint Targets

    Immunotherapy   Cancer Immunotherapy   Targeted Therapy

    B7-H4/Vtcn1/B7S1 代替名

    B7-H4/Vtcn1/B7S1 関連研究

  • Zang X, et al. (2003) B7x: a widely expressed B7 family member that inhibits T cell activation. Proc Natl Acad Sci U S A. 100(18): 10388-92.
  • Suh WK, et al. (2006) Generation and characterization of B7-H4/B7S1/B7x-deficient mice. Mol Cell Biol. 26(17): 6403-11.
  • Zang X, et al. (2007) B7-H3 and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome. Proc Natl Acad Sci U S A. 104(49):19458-63.
  • 注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"