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B2M / Beta-2-microglobulin 抗体, ウサギポリクローナル抗体, Antigen Affinity Purified

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Mouse B2M 抗体製品情報
免疫原:Recombinant Mouse B2M / Beta-2-microglobulin protein (Catalog#50957-M08H)
Clone ID:
Ig タイプ:Rabbit IgG
濃度:
エンドトキシン:
製剤:0.2 μm filtered solution in PBS with 5% trehalose
調製:Produced in rabbits immunized with purified, recombinant Mouse B2M / Beta-2-microglobulin (rM B2M / Beta-2-microglobulin; Catalog#50957-M08H; P01887; Met1-Met119). B2M / Beta-2-microglobulin specific IgG was purified by Mouse B2M / Beta-2-microglobulin affinity chromatography.
Mouse B2M 抗体使用ガイド
特異度:Mouse B2M / Beta-2-microglobulin
アプリケーション:ELISA, IHC-P

ELISA: 0.1-0.2 μg/mL

This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse B2M / Beta-2-microglobulin. The detection limit for Mouse B2M / Beta-2-microglobulin is approximately 0.00975 ng/well.

IHC-P: 0.1-2 μg/mL

保存:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Mouse B2M Antibody IHC Application Image
B2M / Beta-2-microglobulin Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of mouse B2M in mouse skin with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections).
Other B2M Antibody Products
Beta-2 microglobulin/B2M 背景

B2M, also known as β2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(β2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(β2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M(β2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to theα3 chain. Unlikeα3, β2 has no transmembrane region. Directly above β2 lies the α1 chain, which itself is lateral to the α2. In the absence of B2M(β2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M(β2 microglobulin) can indicate non-progression of HIV.

Mouse Beta-2 microglobulin/B2M 参考文献
  • Poulik MD, et al. (1979) Beta 2-Microglobulin: methods and clinical applications. CRC Ctit Rev Clin Lab Sci. 10(3): 225-45.
  • Poulik MD, et al. (1975) Beta2-Microglobulins. Contemp Top Mol Immunol. 4: 157-204.
  • Berggard I. (1976) Beta2-Microglobulins: isolation, properties, and distribution. Fed Proc. 35(5): 1167-70.
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    カタログ: 50957-RP02-200
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    • B2M / Beta-2-microglobulin Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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