Anti-H7N9 Hemagglutinin / HA Antibody (FITC), Rabbit MAb

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Anti-H7N9 Hemagglutinin / HA Antibody (FITC), Rabbit MAb (Rabbit Monoclonal 抗体) の製品情報

製品名
Anti-H7N9 Hemagglutinin / HA Antibody (FITC), Rabbit MAb
検証済のアプリケーション
FCM (Antibody's applications have not been validated with corresponding viruses. Optimal concentrations/dilutions should be determined by the end user.)
特異性
Influenza Hemagglutinin / HA
ソース
Monoclonal Rabbit IgG Clone #002
精製
Protein A
緩衝液
Aqueous solution containing 0.5% BSA and 0.1% sodium azide
標識物
FITC
濃度
10 μl/Test, 0.1 mg/ml
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for twelve months without detectable loss of activity. Protected from prolonged exposure to light. Do not freeze ! Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.

Anti-H7N9 Hemagglutinin / HA Antibody (FITC), Rabbit MAb (Rabbit Monoclonal 抗体) の画像

Flow cytometric analysis of FITC conjugated anti-H7N9-HA antibody on 293 transfected cells. 293 cells were transfected with plasmid DNA of H7N9 (A/Anhui/1/2013) Hemagglutinin (Cat.No. VG40103-G-N), then the cells were collected at 72 hours posttransfection, and the cell surface expression of HA were measured by flowcytometry.

Hemagglutinin / HA 背景情報

The influenza viral Hemagglutinin (HA) protein is a homo trimer with a receptor binding pocket on the globular head of each monomer.HA has at least 18 different antigens. These subtypes are named H1 through H18.HA has two functions. Firstly, it allows the recognition of target vertebrate cells, accomplished through the binding to these cells' sialic acid-containing receptors. Secondly, once bound it facilitates the entry of the viral genome into the target cells by causing the fusion of host endosomal membrane with the viral membrane.The influenza virus Hemagglutinin (HA) protein is translated in cells as a single protein, HA, or hemagglutinin precursor protein. For viral activation, hemagglutinin precursor protein (HA) must be cleaved by a trypsin-like serine endoprotease at a specific site, normally coded for by a single basic amino acid (usually arginine) between the HA1 and HA2 domains of the protein. After cleavage, the two disulfide-bonded protein domains produce the mature form of the protein subunits as a prerequisite for the conformational change necessary for fusion and hence viral infectivity.
完全な名称
Harvey rat sarcoma viral oncogene homolog
参考文献
  • White JM, Hoffman LR, Arevalo JH, et al. (1997). ""Attachment and entry of influenza virus into host cells. Pivotal roles of hemagglutinin"". In Chiu W, Burnett RM, Garcea RL. Structural Biology of Viruses.
  • Suzuki Y (March 2005). ""Sialobiology of influenza: molecular mechanism of host range variation of influenza viruses"". Biol. Pharm. Bull. 28 (3): 399–408.
  • Senne DA, Panigrahy B, Kawaoka Y, et al. (1996). ""Survey of the hemagglutinin (HA) cleavage site sequence of H5 and H7 avian influenza viruses: amino acid sequence at the HA cleavage site as a marker of pathogenicity potential"". Avian Dis. 40 (2): 425–37
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