May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.
ATAD2 protein expression
Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors.
Up-regulated in breast, uterus, colon, ovary, and stomach tumors. Induced in breast cancer cells overexpressing NCOA3 or treated with estrogen. Down-regulated in 5-fluorouracil-resistant derivatives of the colon cancer cell line HCT 116.
ATAD2 protein sequence
This sequence information is just for reference only.From Uniport
ATAD2 cDNA / gene is a gene with protein product which located on 8q24.13. The ATAD2 gene is conserved in chimpanzee, Rhesus monkey, dog, mouse, rat, chicken, zebrafish, and frog. 226 organisms have orthologs with human gene ATAD2.