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ANTXR2 / CMG2  タンパク質

All ANTXR2  Reagents

発現宿主: Human Cells  
15762-H02H-50
15762-H02H-100
50 µg 
100 µg 
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発現宿主: Human Cells  
51131-M02H-50
51131-M02H-100
50 µg 
100 µg 
Add to Cart
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発現宿主: Human Cells  
51131-M08H-50
51131-M08H-100
50 µg 
100 µg 
Add to Cart
  • Slide 1

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ANTXR2 / CMG2 Related Area

ANTXR2 / CMG2 関連経路

    ANTXR2 / CMG2 サマリー & タンパク質情報

    ANTXR2 / CMG2 背景

    サブユニット構造: Binds laminin, and possibly also collagen type IV. Binds to the protective antigen (PA) of Bacillus anthracis in a divalent cation-dependent manner, with the following preference: calcium > manganese > magnesium > zinc. Binding of PA leads to heptamerization of the receptor-PA complex.
    ドメイン: Binding to PA seems to be effected through the VWA domain.
    細胞内位置: Isoform 1: Cell membrane; Single-pass type I membrane protein. Note=Expressed at the cell surface.; Isoform 2: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Note=Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane.; Isoform 3: Secreted.
    組織特異性: Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen. {ECO:0000269|PubMed:14508707}.
    疾患関連性: DISEASE: Hyaline fibromatosis syndrome (HFS) [MIM:228600]: An autosomal recessive syndrome characterized by abnormal growth of hyalinized fibrous tissue usually affecting subcutaneous regions on the scalp, ears, neck, face, hands, and feet. The lesions appear as pearly papules or fleshy nodules. Additional features include gingival hypertrophy, progressive joint contractures resulting in severe limitation of mobility, osteopenia, and osteoporosis. Disease severity is variable. Some individuals manifest symptoms in infancy and have additional visceral or systemic involvement. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to early death. Surviving children may suffer from severely reduced mobility due to joint contractures. Other patients have later onset of a milder disorder affecting only the face and digits. {ECO:0000269|PubMed:12973667, ECO:0000269|PubMed:14508707, ECO:0000269|PubMed:15725249}. Note=The disease is caused by mutations affecting the gene represented in this entry.
    シーケンスの類似性: Belongs to the ATR family. {ECO:0000305}.; Contains 1 VWFA domain. {ECO:0000255|PROSITE-ProRule:PRU00219}.
    General information above from UniProt

    ANTXR2 / CMG2 代替名

    HFS,ISH,JHF,CMG2,CMG-2, [homo-sapiens]
    anthrax toxin receptor 2,ANTXR2,CMG-2,CMG2,HFS,ISH,JHF,capillary morphogenesis gene 2 protein,capillary morphogenesis protein 2, [human]
    anthrax toxin receptor 2,Antxr2,2310046B19Rik,AW561899,CMG-2,CMG2,cI-35, [mouse]
    CMG2,CMG-2,cI-35,AW561899,2310046B19Rik, [mus-musculus]

    ANTXR2 / CMG2 関連研究

    注意:すべての製品は、"研究目的のみに使用するものであり、診断または治療目的に使用するものではありません"