Anti-ALK-1 Antibody

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Anti-ALK-1 Antibody (Rabbit Polyclonal 抗体) の製品情報

製品名
Anti-ALK-1 Antibody
検証済のアプリケーション
WB,ELISA,IHC-P
交差反応
Reacts with: Human
特異性
Human ALK-1
免疫原
Recombinant Human ALK-1 / ACVRL1 protein (Catalog#10066-H08H)
調製
Produced in rabbits immunized with purified, recombinant Human ALK-1 / ACVRL1 (rh ALK-1 / ACVRL1; Catalog#10066-H08H; NP_000011.2; Met1-Gln118). ALK-1 / ACVRL1 specific IgG was purified by Human ALK-1 / ACVRL1 affinity chromatography.
ソース
Polyclonal Rabbit IgG
精製
Protein A & Antigen Affinity
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-ALK-1 Antibody (Rabbit Polyclonal 抗体) 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
WB 1:500-1:1000
ELISA 1:25000-1:50000
IHC-P 1:2000-1:10000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-ALK-1 Antibody (Rabbit Polyclonal 抗体) の画像

Immunochemical staining of human ALK1 in human liver with rabbit polyclonal antibody at 1:5000 dilution, formalin-fixed paraffin embedded sections.

Anti-ALK1 rabbit polyclonal antibody at 1:500 dilution

Lane A: Jurkat Whole Cell Lysate

Lysates/proteins at 30 μg per lane.

Secondary

Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution.

Developed using the Odyssey technique.

Performed under reducing conditions.

Predicted band size:56 kDa

Observed band size:54 kDa

Anti-ALK-1 Antibody: 別名

Anti-ACVRLK1 Antibody; Anti-ALK-1 Antibody; Anti-ALK1 Antibody; Anti-HHT Antibody; Anti-HHT2 Antibody; Anti-ORW2 Antibody; Anti-SKR3 Antibody; Anti-TSR-I Antibody

ALK-1 背景情報

Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
氏名
activin A receptor type II-like 1
参考文献
  • French Rendu-Osler network,et al. (2004) Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France. Hum Mutat. 23(4): 289-299.
  • Simon M, et al. (2006) Association of a polymorphism of the ACVRL1 gene with sporadic arteriovenous malformations of the central nervous system. J Neurosurg. 104(6): 945-9.
  • Argyriou L, et al. (2006) Novel mutations in the ENG and ACVRL1 genes causing hereditary hemorrhagic teleangiectasia. Int J Mol Med. 17(4):655-9.
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