All ACVR2A reagents are produced in house and quality controlled, including 2 ACVR2A Antibody, 52 ACVR2A Gene, 4 ACVR2A Lysate, 4 ACVR2A Protein, 2 ACVR2A qPCR. All ACVR2A reagents are ready to use.
Recombinant ACVR2A proteins are expressed by HEK293 Cells with fusion tags as C-His, C-human IgG1-Fc & His, C-human IgG1-Fc.
ACVR2Aantibodies are validated with different applications, which are WB, ELISA, IP.
ACVR2AcDNA clones are full length sequence confirmed and expression validated. There are 13 kinds of tags for each ACVR2A of different species, especially GFP tag, OFP tag, FLAG tag and so on. There are three kinds of vectors for choice, cloning vector, expression vector and lentivrial expression vector.
ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.