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ACVR2A   Protein, Antibody, ELISA Kit, cDNA Clone

発現宿主: Human Cells  
10257-H08H-200
10257-H08H-100
200 µg 
100 µg 
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発現宿主: Human Cells  
10257-H02H-200
10257-H02H-100
200 µg 
100 µg 
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発現宿主: Human Cells  
50613-M08H-200
50613-M08H-100
200 µg 
100 µg 
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発現宿主: Human Cells  
50613-M03H-200
50613-M03H-100
200 µg 
100 µg 
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  • Slide 1

ACVR2A  Related Area

ACVR2A  関連経路

ACVR2A  サマリー & タンパク質情報

ACVR2A  背景

遺伝子の概要: ACVR2A gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. [provided by RefSeq, Jul 2008]
General information above from NCBI
触媒活性: ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
補因子: Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000250};
サブユニット構造: Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity). {ECO:0000250}.
細胞内位置: Membrane; Single-pass type I membrane protein.
シーケンスの類似性: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. {ECO:0000305}.; Contains 1 protein kinase domain. {ECO:0000255|PROSITE-ProRule:PRU00159}.
General information above from UniProt

ACVR2A and ACVR2B are two activin type II receptors. ACVR2A has been shown to interact with INHBA, SYNJ2BP and ACVR1B. The bovine ACVR2A gene encodes a protein of 513 amino acids which is highly homologous (approximately 98% identity) to the rat, mouse, and human ACVR2A proteins. Inactivation of ACVR2A is a common event in prostate cancer cells suggesting it may play an important role in the development of prostate cancer. The ACVR2A gene is a putative tumor suppressor gene that is frequently mutated in microsatellite-unstable colon cancers (MSI-H colon cancers). Frameshift mutation of ACVR2A may contribute to MSI-H colon tumorigenesis via disruption of alternate TGF-beta effector pathways.

ACVR2A  代替名

ACVR2,ACTRII, [homo-sapiens]
ACVR2,ACVR2A,ACTRII, [human]
Acvr2a,ActrIIa,RP23-139F8.3,Acvr2,TactrII, [mouse]
Acvr2,ActrIIa,TactrII, [mus-musculus]

ACVR2A  関連研究

  • Albertson RC, et al. (2005) Zebrafish acvr2a and acvr2b exhibit distinct roles in craniofacial development. Developmental dynamics 233(4): 1405-18.
  • Chung H, et al. (2008) Mutation rates of TGFBR2 and ACVR2 coding microsatellites in human cells with defective DNA mismatch repair. PloS one 3(10): e3463.
  • Fitzpatrick E, et al. (2009) Genetic association of the activin A receptor gene (ACVR2A) and pre-eclampsia. Molecular human reproduction 15(3):195-204.
  • Roten LT, et al. (2009) Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study). EJHG. 17(2): 250-7.
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