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ABHD4  ELISA Pair Set

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ABHD4

ABHD4 ELISA Pair Set

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ABHD4 関連経路

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    ABHD4 サマリー & タンパク質情報

    ABHD4 背景

    シーケンスの類似性: Belongs to the peptidase S33 family. ABHD4/ABHD5 subfamily. {ECO:0000305}.
    General information above from UniProt

    Abhydrolase domain containing 4 (ABHD4), also known as alpha/beta-hydrolase 4 (ABH4) , or lyso-N-acylphosphatidylethanolamine lipase, which belongs to the ABHD4/ABHD5 subfamily of peptidase S33 family. Abhydrolase domain containing (ABHD) gene was a small group belongs to alpha/beta hydrolase superfamily. Known members of this group are all found to be involved in important biochemical processes and related to various diseases. The alpha/beta-hydrolase 4 (ABH4) is a lysophospholipase/phospholipase B that selectively hydrolyzes N-acyl phosphatidylethanolamines (NAPEs) and lysoNAPEs. ABH4 accepts lysoNAPEs bearing both saturated and polyunsaturated N-acyl chains as substrates and displays a distribution that closely mirrors lysoNAPE-lipase activity in mouse tissues. The existence of an NAPE-PLD-independent route for NAE biosynthesis and suggest that ABH4 plays a role in this metabolic pathway by acting as a (lyso)NAPE-selective lipase.

    ABHD4 代替名

    ABH4, [homo-sapiens]
    ABH4,ABHD4,FLJ12816, [human]
    1110035H23Rik,Abh4,ABHD4,AI429574, [mouse]
    Abh4,AI429574,1110035H23Rik, [mus-musculus]

    ABHD4 関連研究

  • Li F, et al. (2009) An unannotated alpha/beta hydrolase superfamily member, ABHD6 differentially expressed among cancer cell lines. Mol Biol Rep. 36(4): 691-6.
  • Simon G.M, et al. (2006) Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta hydrolase 4 in this pathway. J. Biol. Chem. 281: 26465-72.
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