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    ABCG2 サマリー & タンパク質情報

    ABCG2 背景

    サブユニット構造: Monomer under reducing conditions, the minimal functional units is a homodimer; disulfide-linked, but the major oligomeric form in plasma membranes is a homotetramer with possibility of higher order oligomerization up to homododecamers. {ECO:0000269|PubMed:15001581, ECO:0000269|PubMed:17686774}.
    ドメイン: The extracellular loop 3 (ECL3) is involved in binding porphyrins and transfer them to other carriers, probably albumin. {ECO:0000269|PubMed:20705604}.
    細胞内位置: Cell membrane; Multi-pass membrane protein. Mitochondrion membrane; Multi-pass membrane protein.
    組織特異性: Highly expressed in placenta. Low expression in small intestine, liver and colon. {ECO:0000269|PubMed:9850061, ECO:0000269|PubMed:9861027}.
    誘導: Up-regulated in brain tumors.
    翻訳後: Glycosylation-deficient ABCG2 is normally expressed and functional. {ECO:0000269|PubMed:15807535}.
    シーケンスの類似性: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. {ECO:0000305}.; Contains 1 ABC transmembrane type-2 domain. {ECO:0000305}.; Contains 1 ABC transporter domain. {ECO:0000255|PROSITE-ProRule:PRU00434}.
    General information above from UniProt

    ABCG2 代替名

    MRX,MXR,ABCP,BCRP,BMDP,MXR1,ABC15,BCRP1,CD338,GOUT1,CDw338,UAQTL1,EST157481, [homo-sapiens]
    MXR,ABCP,BCRP,MXR1,ABC15,Bcrp1,AI428558, [mus-musculus]

    ABCG2 関連研究