ABCC4: ABCC4 Protein | ABCC4 Antibody

ABCC4 Gene family

ABCC4 Protein

ABCC4 protein function

May be an organic anion pump relevant to cellular detoxification.

ABCC4 protein expression

Tissue specificity

Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.

ABCC4 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

ABCC4 Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]