ABCB9: ABCB9 Protein | ABCB9 Antibody

ABCB9 Gene family

ABCB9 Protein

ABCB9 protein function

ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.

ABCB9 protein expression

Tissue specificity

Highly expressed in testis, and at moderate levels in brain, spinal cord, and thyroid. Not expressed in monocytes but strongly expressed during differentiation of monocytes to dendritic cells and macrophages.

Induction

Not induced by interferon-gamma.

ABCB9 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    766.00
  • Mass (Da)
    84.00

ABCB9 Antibody

There are 1 ABCB9 antibodies which are validated in multiple tissues with various applications, including IHC-P. There are 1 ABCB9 antibody for IHC-P. Among all these ABCB9 antibodies, there are 1 anti-ABCB9 rabbit polyclonal antibodies . All the ABCB9 anbodies are produced in house and all are in stock. ABCB9 antibody customerized service is available.

ABCB9 Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]