Adracalin: Adracalin Protein | Adracalin Antibody

Adracalin Gene family

Adracalin Protein

Adracalin protein function

Plays a role in the normal development of the peripheral and central nervous system.

Adracalin protein expression

Tissue specificity

Widely expressed (PubMed:11159947, PubMed:16022285). Particularly abundant in cerebellum, corpus callosum, adrenal gland, pituitary gland, gastrointestinal structures and fetal lung (PubMed:11159947).

Adracalin protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    546.00
  • Mass (Da)
    59.00

Adracalin Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]