Alpha4GnT/A4GNT: Alpha4GnT/A4GNT Protein | Alpha4GnT/A4GNT Antibody

Alpha4GnT/A4GNT Gene family

Alpha4GnT/A4GNT Protein

Alpha4GnT/A4GNT protein function

Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans (PubMed:10430883). Necessary for the synthesis of type III mucin which is specifically produced in the stomach, duodenum, and pancreatic duct (PubMed:10430883). May protect against inflammation-associated gastric adenocarcinomas (By similarity).

Alpha4GnT/A4GNT protein expression

Tissue specificity

Detected in stomach and pancreas.

Alpha4GnT/A4GNT protein sequence

This sequence information is just for reference only.From Uniport

  • Length
  • Mass (Da)

Alpha4GnT/A4GNT Gene

The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified. [NCBI]