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CD137L/4-1BBL/TNFSF9  タンパク質

All 4-1BBL Reagents

発現宿主: Human Cells  
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15693-H01H-5
15693-H01H-20
15693-H01H-100
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製品の説明: Active  
発現宿主: Human Cells  
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50067-M07H-20
50067-M07H-50
50067-M07H-5
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50 µg 
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発現宿主: Human Cells  
  • Slide 1
80166-R01H-20
80166-R01H-50
20 µg 
50 µg 
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発現宿主: Human Cells  
  • Slide 1
80166-R07H-20
80166-R07H-50
20 µg 
50 µg 
Add to Cart

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CD137L/4-1BBL/TNFSF9 関連経路

CD137L/4-1BBL/TNFSF9 関連製品

CD137L/4-1BBL/TNFSF9 サマリー & タンパク質情報

CD137L/4-1BBL/TNFSF9 背景

遺伝子の概要: The protein encoded by TNFSF9 gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by TNFSF9 gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]
General information above from NCBI
サブユニット構造: Homotrimer.
細胞内位置: Membrane; Single-pass type II membrane protein.
組織特異性: Expressed in brain, placenta, lung, skeletal muscle and kidney.
シーケンスの類似性: Belongs to the tumor necrosis factor family.C
General information above from UniProt

4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In additon, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.

CD137L/4-1BBL/TNFSF9 代替名

CD137L/4-1BBL/TNFSF9 関連研究

  • Cheung CT, (2007) Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis. Lab Invest. 87(7): 651-61.
  • Wang C, et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev. 229(1): 192-215.
  • Habib-Agahi M, et al. (2009) 4-1BBL costimulation retrieves CD28 expression in activated T cells. Cell Immunol. 256(1-2): 39-46.
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