Anti-4-1BBL Antibody

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Anti-4-1BBL Antibody (Rabbit Polyclonal 抗体) の製品情報

製品名
Anti-4-1BBL Antibody
検証済のアプリケーション
ELISA
交差反応
Reacts with: Mouse
特異性
Mouse 4-1BBL
免疫原
Recombinant Mouse TNFSF9 protein (Catalog#50067-M07H)
調製
Produced in rabbits immunized with purified, recombinant Mouse TNFSF9 / 4-1BBL extracellular domain (rM TNFSF9; Catalog#50067-M07H; Arg 104-Glu 309; NP_033430.1). Total IgG was purified by Protein A affinity chromatography.
ソース
Polyclonal Rabbit IgG
精製
Protein A
緩衝液
0.2 μm filtered solution in PBS
標識物
Unconjugated
状態
Liquid
配送方法
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
保存条件
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-4-1BBL Antibody (Rabbit Polyclonal 抗体) 検証済のアプリケーション

アプリケーション 推奨希釈率/用量
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-4-1BBL Antibody: Alternative Names

Anti-4-1BB-L Antibody; Anti-4-1BBL Antibody; Anti-AI848817 Antibody; Anti-Cd137l Antibody; Anti-Ly63l Antibody

4-1BBL Background Information

4-1BBL is the high affinity ligand of 4-1BB, also known as CD137L or TNFSF9. It is shown to be a type II surface glycoprotein belonging to the TNF superfamily. Expression of 4-1BBL is restricted to APCs, such as dendritic cells, macrophages, and activated B cells. Members of the TNF-TNF receptor superfamily have been shown to play critical roles in regulating cellular activation, differentiation and apoptosis. Several studies have reported that 4-1BBL/4-1BB interaction provided a co-stimulatory signal to T cells, and increased T cell proliferation and cytokines production. In additon, 4-1BBL is involved in cancers, infectious diseases and autoimmune diseases.
Full Name
tumor necrosis factor (ligand) superfamily, member 9
References
  • Cheung CT, (2007) Neutralizing anti-4-1BBL treatment improves cardiac function in viral myocarditis. Lab Invest. 87(7): 651-61.
  • Wang C, et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol Rev. 229(1): 192-215.
  • Habib-Agahi M, et al. (2009) 4-1BBL costimulation retrieves CD28 expression in activated T cells. Cell Immunol. 256(1-2): 39-46.
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