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14-3-3 sigma/Stratifin/YWHAS  抗体

All YWHAS Reagents

反応度: Human  
アプリケーション: 
10838-T54-50
10838-T54-200
10838-T54-100
50 µg 
200 µg 
100 µg 
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反応度: Human  
アプリケーション: ELISA  
10838-RP01-400
10838-RP01-200
10838-RP01-100
400 µg 
200 µg 
100 µg 
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    反応度: Human  
    アプリケーション: ELISA  
    10838-RP02-50
    10838-RP02-200
    10838-RP02-100
    50 µg 
    200 µg 
    100 µg 
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      反応度: Human  
      アプリケーション: FCM  
      10838-MM02-P-25
      10838-MM02-P-100
      25 Test 
      100 Tests 
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      反応度: Human  
      アプリケーション: FCM  
      10838-MM02-50
      10838-MM02-200
      10838-MM02-100
      50 µg 
      200 µg 
      100 µg 
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      反応度: Mouse  
      アプリケーション: ELISA  WB  IHC-P  IP  
      50576-RP02-50
      50576-RP02-200
      50576-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
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      反応度: Mouse  
      アプリケーション: ELISA  
      50576-RP01-400
      50576-RP01-200
      50576-RP01-100
      400 µg 
      200 µg 
      100 µg 
      Add to Cart

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          14-3-3 sigma/Stratifin/YWHAS サマリー & タンパク質情報

          14-3-3 sigma/Stratifin/YWHAS 背景

          遺伝子の概要: OMIM - description for 14-3-3 sigma (Stratifin, YWHAS):
          General information above from NCBI
          サブユニット構造: Homodimer. Interacts with KRT17 and SAMSN1 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GAB2. Interacts with SRPK2. Interacts with COPS6. Interacts with RFWD2; this interaction leads to proteasomal degradation. {ECO:0000250, ECO:0000269|PubMed:15282546, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:19172738, ECO:0000269|PubMed:19592491, ECO:0000269|PubMed:21625211, ECO:0000269|PubMed:22634725}.
          細胞内位置: Cytoplasm. Nucleus {ECO:0000250}. Secreted. Note=May be secreted by a non-classical secretory pathway.
          組織特異性: Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
          翻訳後: Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation. {ECO:0000269|PubMed:18382127}.
          シーケンスの類似性: Belongs to the 14-3-3 family. {ECO:0000305}.
          General information above from UniProt

          14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathway. More than 100 signaling proteins have been reported as 14-3-3 ligands including kinases, phosphatases, and transmembrane receptors, and the binding generally results in the modulation of the activity of the binding partner. YWHAE exists as a homodimer and present mainly in tissues enriched in stratified squamous keratinising epithelium. YWHAS has been repoted to interact with KRT17 and GAB2, and may regulate protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway upon binding to KRT17. Additionally, YWHAS (SFN) may also act as a p53-regulated inhibitor of G2/M progression.

          14-3-3 sigma/Stratifin/YWHAS 代替名

          14-3-3 sigma/Stratifin/YWHAS 関連研究

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