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14-3-3 sigma / Stratifin / YWHAS 抗体, マウスモノクローナル抗体

  • 14-3-3 sigma / Stratifin / YWHAS Antibody, Mouse MAb, Flow Cytometry
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人々 SFN 抗体製品情報
免疫原:Recombinant Human 14-3-3 sigma / Stratifin / YWHAS Protein (Catalog#10838-HNCE)
Clone ID:02
Ig タイプ:Mouse IgG1
濃度:
エンドトキシン:
製剤:0.2 μm filtered solution in PBS
調製:This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human 14-3-3 sigma / Stratifin / YWHAS (rh 14-3-3 sigma / Stratifin / YWHAS; Catalog#10838-HNCE; NP_006133.1; Met1-Ser248). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
人々 SFN Antibody FC Application Image
14-3-3 sigma / Stratifin / YWHAS Antibody, Mouse MAb, Flow Cytometry
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Caption:
Flow cytometric analysis of Human SFN expression on HeLa cells. Cells were stained with purified anti-Human SFN, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Other SFN Antibody Products
14-3-3 sigma/Stratifin/YWHAS 背景

14-3-3 protein sigma (YWHAS), also known as stratifin (SFN) and epithelial cell marker protein 1, is a member of the14-3-3 proteins which are a family of conserved regulatory molecules expressed in all eukaryotic cells. The name 14-3-3 refers to the particular elution and migration pattern of these proteins on DEAE-cellulose chromatography and starch-gel electrophoresis. The 14-3-3 proteins eluted in the 14th fraction of bovine brain homogenate and were found on positions 3.3 of subsequent electrophoresis. There are seven genes that encode 14-3-3s in most mammals. 14-3-3 proteins have been identified as adapter proteins implicated in the regulation of a large spectrum of both general and specialized signaling pathway. More than 100 signaling proteins have been reported as 14-3-3 ligands including kinases, phosphatases, and transmembrane receptors, and the binding generally results in the modulation of the activity of the binding partner. YWHAE exists as a homodimer and present mainly in tissues enriched in stratified squamous keratinising epithelium. YWHAS has been repoted to interact with KRT17 and GAB2, and may regulate protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway upon binding to KRT17. Additionally, YWHAS (SFN) may also act as a p53-regulated inhibitor of G2/M progression.

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カタログ: 10838-MM02-50
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