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人々 14-3-3 epsilon / YWHAE 蛋白質

  • Human 14-3-3 epsilon / YWHAE Protein SDS-PAGE
データシートレビュー関連製品プロトコル
人々 YWHAE タンパク質製品情報
同意語:14-3-3E,HEL2,KCIP-1,MDCR,MDS
タンパク質構造:A DNA sequence encoding the human YWHAE (NP_006752.1) (Met 1-Gln 255) was expressed, with two additional amino acids (Gly & Pro) at the N-terminus.
:Human
発現宿主:E. coli
フォーム & 配送:In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
人々 YWHAE タンパク質 QC 試験
純度:> 96 % as determined by SDS-PAGE
エンドトキシン:Please contact us for more information.
安定性:Samples are stable for up to twelve months from date of receipt at -70℃
予測される N ターミナル:Gly
分子質量:The recombinant human YWHAE consists of 257 amino acids and has a predicted molecular mass of 29.4 kDa as estimated in SDS-PAGE under reducing conditions.
製剤:Lyophilized from sterile 20mM Tris, 150mM NaCl, 0.25mM DTT, 25% glycerol, 0.5mM GSH, pH 7.5
1. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Specific concentrations are included in the hardcopy of COA.
2. Please contact us for any concerns or special requirements.
人々 YWHAE タンパク質使用ガイド
保存:Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
再構成:A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
人々 YWHAE Protein SDS-PAGE
Human 14-3-3 epsilon / YWHAE Protein SDS-PAGE
Other YWHAE Recombinant Protein Products
10842-HNCE
14-3-3 epsilon/YWHAE 背景

YWHAE, also known as 14-3-3 epsilon, mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 epsilon / YWHAE is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 epsilon / YWHAE is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. YWHAE interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 epsilon / YWHAE is implicated in the regulation of a large spectrum of both general and specialized signaling pathways. 14-3-3 epsilon / YWHAE Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. This Binding generally results in the modulation of the activity of the binding partner.

人々 14-3-3 epsilon/YWHAE 参考文献
  • Ikeda M, et al. (2008) Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Hum Mol Genet. 17(20): 3212-22.
  • Mignon-Ravix C, et al. (2010) Deletion of YWHAE in a patient with periventricular heterotopias and pronounced corpus callosum hypoplasia. J Med Genet. 47(2): 132-6.
  • Nagamani SC, et al. (2009) Microdeletions including YWHAE in the Miller-Dieker syndrome region on chromosome 17p13.3 result in facial dysmorphisms, growth restriction, and cognitive impairment. J Med Genet. 46(12): 825-33.
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    カタログ: 10842-HNCE-50
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